I've yet to encounter a single person who knows what this is referencing, but alas, here it is. It was a response to the Ford safety commercials featuring the monstrous Esuvee.
Esuvee Snacks
By Chris Toumanian
Comic transcript and visual description
A loud ‘THUD’ startles a man holding a mug. He says: ‘Wha... what is that?!’
A friend rides a giant furry creature with headlights and a grille. He says: ‘Hey Tbone, check out my new ride!’
Tbone asks: ‘So uh, what kind of mileage does that thing get?’ His friend answers: ‘About eight gallons per mile.’ Tbone asks: ‘How can you afford that?’
The rider says: ‘Well, it mostly just feeds on inferior vehicles.’ The creature growls, ‘GRRRR.....’, near a red SUV.